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The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro

Cancer cells are dependent upon an abundance of ribosomes to maintain rapid cell growth and proliferation. The rate-limiting step of ribosome biogenesis is ribosomal RNA (rRNA) synthesis by RNA polymerase I (Pol I). Therefore, a goal of the cancer therapeutic field is to develop and characterize Pol...

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Detalles Bibliográficos
Autores principales:	Jacobs, Ruth Q., Huffines, Abigail K., Laiho, Marikki, Schneider, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683726/ https://www.ncbi.nlm.nih.gov/pubmed/34838819 http://dx.doi.org/10.1016/j.jbc.2021.101450

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