Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity

BACKGROUND: Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung adenocarcinoma that impact morbidity and mortality worldwide. Elucidating underlying disease pathogene...

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Detalles Bibliográficos
Autores principales: Zhou, B., Stueve, T. R., Mihalakakos, E. A., Miao, L., Mullen, D., Wang, Y., Liu, Y., Luo, J., Tran, E., Siegmund, K. D., Lynch, S. K., Ryan, A. L., Offringa, I. A., Borok, Z., Marconett, C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684104/
https://www.ncbi.nlm.nih.gov/pubmed/34922464
http://dx.doi.org/10.1186/s12864-021-08152-6

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