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An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors

Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin,...

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Detalles Bibliográficos
Autores principales: Nwanaji-Enwerem, Jamaji C., Chung, Felicia Fei-Lei, Van der Laan, Lars, Novoloaca, Alexei, Cuenin, Cyrille, Johansson, Harriet, Bonanni, Bernardo, Hubbard, Alan E., Smith, Martyn T., Hartman, Sheri J., Cardenas, Andres, Sears, Dorothy D., Herceg, Zdenko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684118/
https://www.ncbi.nlm.nih.gov/pubmed/34920739
http://dx.doi.org/10.1186/s13148-021-01218-y
Descripción
Sumario:Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin, or weight loss with placebo interventions for 6 months. Epigenetic age was correlated with chronological age (r = 0.20–0.86; P < 0.005). However, no significant epigenetic aging associations were observed by intervention arms. Consistent with published reports in non-cancer patients, 6 months of metformin therapy may be inadequate to observe expected epigenetic age deceleration. Longer duration studies are needed to better characterize these relationships. Trial Registration: Registry Name: ClincialTrials.Gov. Registration Number: NCT01302379. Date of Registration: February 2011. URL: https://clinicaltrials.gov/ct2/show/NCT01302379 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-021-01218-y.