Cargando…

A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control

BACKGROUND: The enhanced thrombotic milieu in diabetes contributes to increased risk of vascular events. Aspirin, a key antiplatelet agent, has inconsistent effects on outcomes in diabetes and the best dosing regimen remains unclear. This work investigated effects of aspirin dose and interaction wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parker, William A. E., Sagar, Rebecca, Kurdee, Zeyad, Hawkins, Fladia, Naseem, Khalid M., Grant, Peter J., Storey, Robert F., Ajjan, Ramzi A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684134/ https://www.ncbi.nlm.nih.gov/pubmed/34920734 http://dx.doi.org/10.1186/s12933-021-01427-y

Ejemplares similares

Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels
por: Parker, William A. E., et al.
Publicado: (2020)

Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic parameters in people with type 1 diabetes: a randomised controlled preliminary trial
por: O’Mahoney, Lauren L., et al.
Publicado: (2020)

Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes
por: Swoboda, Peter P., et al.
Publicado: (2018)

Non-Traditional Pathways for Platelet Pathophysiology in Diabetes: Implications for Future Therapeutic Targets
por: Sagar, Rebecca C., et al.
Publicado: (2022)

Antithrombotic therapy in diabetes: which, when, and for how long?
por: Ajjan, Ramzi A, et al.
Publicado: (2021)

The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?
por: Altman, Raul, et al.
Publicado: (2004)

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation
por: Hess, Katharina, et al.
Publicado: (2012)

Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis
por: Sobczak, Amélie I. S., et al.
Publicado: (2020)

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome
por: Parker, William A.E., et al.
Publicado: (2019)

The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control
por: Casanova, F., et al.
Publicado: (2017)

SUN-085 Assessing the Impact of Disease Activity on Clot Formation and Lysis in Patients with Acromegaly
por: Kyriakakis, Nikolaos, et al.
Publicado: (2019)

SUN-075 Higher Fibrinogen and Clot Density in Patients with Acromegaly: The Role of Adverse Body Composition to the Increased Thrombotic Potential
por: Kyriakakis, Nikolaos, et al.
Publicado: (2019)

Use of Cerebrolysin in combination with high‐dose aspirin antithrombotic treatment of ischemic stroke: A case report
por: Borisevich, Alexander, et al.
Publicado: (2021)

Full versus Baby Dose Aspirin for Antithrombotic Prophylaxis in Free Tissue Transfer: Does Size Matter?
por: Karamanos, Efstathios, et al.
Publicado: (2022)

Antithrombotic therapy in atrial fibrillation: aspirin is rarely the right choice
por: Sabir, Ian N, et al.
Publicado: (2013)

Antithrombotic therapy after mitral valve repair: VKA or aspirin?
por: van der Wall, Sake J., et al.
Publicado: (2018)

Improved glycaemic control by switching from insulin NPH to insulin glargine: a retrospective observational study
por: Sharplin, Peter, et al.
Publicado: (2009)

Association Between Low-Dose Aspirin Use and Colorectal Cancer Incidence in Taiwan
por: Lin, Hui-Min Diana, et al.
Publicado: (2020)

New Antithrombotic Drugs in Acute Coronary Syndrome
por: Zwart, Bastiaan, et al.
Publicado: (2020)

Beta blocker use in subjects with type 2 diabetes mellitus and systolic heart failure does not worsen glycaemic control
por: Wai, Bryan, et al.
Publicado: (2012)

Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
por: Price, Jackie F, et al.
Publicado: (2008)

Association of Long-term Use of Low-Dose Aspirin as Chemoprevention With Risk of Lung Cancer
por: Ye, Shinhee, et al.
Publicado: (2019)

Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial
por: Chiavaroli, Laura, et al.
Publicado: (2016)

Influence of Vitamin E Supplementation on Glycaemic Control: A Meta-Analysis of Randomised Controlled Trials
por: Xu, Renfan, et al.
Publicado: (2014)

Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU)
por: Jull, Andrew, et al.
Publicado: (2017)

Fibrin Clot Structure and Platelet Aggregation in Patients with Aspirin Treatment Failure
por: Neergaard-Petersen, Søs, et al.
Publicado: (2013)

Reduction in HbA1c using professional flash glucose monitoring in insulin-treated type 2 diabetes patients managed in primary and secondary care settings: A pilot, multicentre, randomised controlled trial
por: Ajjan, Ramzi A, et al.
Publicado: (2019)

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin
por: Platt, Brooks, et al.
Publicado: (2020)

Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials
Publicado: (2021)

Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials
por: Chiavaroli, Laura, et al.
Publicado: (2021)

Lack of correlation between the optimal glycaemic control and coronary micro vascular dysfunction in patients with diabetes mellitus: a cross sectional study
por: Valenzuela-Garcia, Luis Felipe, et al.
Publicado: (2015)

Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction
por: Everett, Colin C, et al.
Publicado: (2020)

Reduction in cardiovascular mortality following severe hypoglycemia in individuals with type 2 diabetes: the role of a pragmatic and structured intervention: Structured intervention for community hypoglycemia
por: Pearson, Sam M., et al.
Publicado: (2021)

Effect of a single intraoperative dose of dexamethasone on glycaemic profile in postoperative patients - A double-blind randomised controlled study
por: Peter, Vigil, et al.
Publicado: (2022)

Risk of atrial fibrillation in persons with type 2 diabetes and the excess risk in relation to glycaemic control and renal function: a Swedish cohort study
por: Seyed Ahmadi, Shilan, et al.
Publicado: (2020)

The Effectiveness of Pharmacological and Non-Pharmacological Interventions for Improving Glycaemic Control in Adults with Severe Mental Illness: A Systematic Review and Meta-Analysis
por: Taylor, Johanna, et al.
Publicado: (2017)

Prolonged Inflammatory Response Post-Hypoglycemia: Mechanistic Insights Into the Relationship Between Low Glucose and Cardiovascular Risk
por: Iqbal, Ahmed, et al.
Publicado: (2022)

Inappropriate combination of warfarin and aspirin
por: Turan, Burak, et al.
Publicado: (2016)

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study
por: Sudheesh, K, et al.
Publicado: (2015)

The effects of treatment with liraglutide on atherothrombotic risk in obese young women with polycystic ovary syndrome and controls
por: Kahal, Hassan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4u2t9jtcrm9cc2g069pkmo9727