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Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

BACKGROUND: Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic. METHODS: We used TNBC cells and xenografted mice as models to explore triptonide-mediated inhibition of TNBC metastas...

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Detalles Bibliográficos
Autores principales:	Zhang, Mengli, Meng, Mei, Liu, Yuxi, Qi, Jindan, Zhao, Zhe, Qiao, Yingnan, Hu, Yanxing, Lu, Wei, Zhou, Zhou, Xu, Peng, Zhou, Quansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684143/ https://www.ncbi.nlm.nih.gov/pubmed/34922602 http://dx.doi.org/10.1186/s13058-021-01488-7

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