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Editing out HIV: application of gene editing technology to achieve functional cure
Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684261/ https://www.ncbi.nlm.nih.gov/pubmed/34922576 http://dx.doi.org/10.1186/s12977-021-00581-1 |
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author | Xun, Jingna Zhang, Xinyu Guo, Shuyan Lu, Hongzhou Chen, Jun |
author_facet | Xun, Jingna Zhang, Xinyu Guo, Shuyan Lu, Hongzhou Chen, Jun |
author_sort | Xun, Jingna |
collection | PubMed |
description | Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. [Image: see text] |
format | Online Article Text |
id | pubmed-8684261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86842612021-12-20 Editing out HIV: application of gene editing technology to achieve functional cure Xun, Jingna Zhang, Xinyu Guo, Shuyan Lu, Hongzhou Chen, Jun Retrovirology Review Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. [Image: see text] BioMed Central 2021-12-18 /pmc/articles/PMC8684261/ /pubmed/34922576 http://dx.doi.org/10.1186/s12977-021-00581-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Xun, Jingna Zhang, Xinyu Guo, Shuyan Lu, Hongzhou Chen, Jun Editing out HIV: application of gene editing technology to achieve functional cure |
title | Editing out HIV: application of gene editing technology to achieve functional cure |
title_full | Editing out HIV: application of gene editing technology to achieve functional cure |
title_fullStr | Editing out HIV: application of gene editing technology to achieve functional cure |
title_full_unstemmed | Editing out HIV: application of gene editing technology to achieve functional cure |
title_short | Editing out HIV: application of gene editing technology to achieve functional cure |
title_sort | editing out hiv: application of gene editing technology to achieve functional cure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684261/ https://www.ncbi.nlm.nih.gov/pubmed/34922576 http://dx.doi.org/10.1186/s12977-021-00581-1 |
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