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Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD

BACKGROUND: Nuclear factor E2-related factor 2 (Nrf2) is involved in oxidative stress and lung inflammation and regulates the etiology of chronic obstructive pulmonary disease (COPD). Ferroptosis is characterized by the accumulation of lipid reactive oxygen species (ROS) via ferrous ion-dependent Fe...

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Detalles Bibliográficos
Autores principales:	Zhang, Zixiao, Fu, Congli, Liu, Jiaxin, Sai, Xiaoyan, Qin, Chu, Di, Tingting, Yang, Yue, Wu, Yan, Bian, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684379/ https://www.ncbi.nlm.nih.gov/pubmed/34934311 http://dx.doi.org/10.2147/COPD.S340113

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