A Crohn’s Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling

BACKGROUND AND AIMS: Differential responsiveness to interleukin [IL]-2 between effector CD4(+) T cells [T(eff)] and regulatory T cells [T(reg)] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP] rs61839660, located within IL2RA [CD25], has been associated with t...

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Detalles Bibliográficos
Autores principales: Goldberg, Rimma, Clough, Jennie N, Roberts, Luke B, Sanchez, Jenifer, Kordasti, Shahram, Petrov, Nedyalko, Hertweck, Arnulf, Lorenc, Anna, Jackson, Ian, Tasker, Scott, Appios, Anna, Omer, Omer, Parkes, Miles, Prescott, Natalie, Jenner, Richard G, Irving, Peter M, Lord, Graham M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684452/
https://www.ncbi.nlm.nih.gov/pubmed/34120187
http://dx.doi.org/10.1093/ecco-jcc/jjab103

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