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Substrate specificity of Chondroitinase ABC I based on analyses of biochemical reactions and crystal structures in complex with disaccharides

Chondroitinase ABC I (cABC-I) is the enzyme which cleaves the β-1,4 glycosidic linkage of chondroitin sulfate (CS) by β-elimination. To elucidate more accurately the substrate specificity of cABC-I, we evaluated the kinetic parameters of cABC-I and its reactivity with CS isomers displaying less stru...

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Detalles Bibliográficos
Autores principales:	Takashima, Makoto, Watanabe, Ippei, Miyanaga, Akimasa, Eguchi, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684500/ https://www.ncbi.nlm.nih.gov/pubmed/34392362 http://dx.doi.org/10.1093/glycob/cwab086

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