Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a ba...

Descripción completa

Detalles Bibliográficos
Autores principales: Rawson, Timothy M, Wilson, Richard C, Moore, Luke S P, Macgowan, Alasdair P, Lovering, Andrew M, Bayliss, Mark, Kyriakides, Mathew, Gilchrist, Mark, Roberts, Jason A, Hope, William W, Holmes, Alison H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684501/
https://www.ncbi.nlm.nih.gov/pubmed/34934774
http://dx.doi.org/10.1093/ofid/ofab573
_version_ 1784617632166576128
author Rawson, Timothy M
Wilson, Richard C
Moore, Luke S P
Macgowan, Alasdair P
Lovering, Andrew M
Bayliss, Mark
Kyriakides, Mathew
Gilchrist, Mark
Roberts, Jason A
Hope, William W
Holmes, Alison H
author_facet Rawson, Timothy M
Wilson, Richard C
Moore, Luke S P
Macgowan, Alasdair P
Lovering, Andrew M
Bayliss, Mark
Kyriakides, Mathew
Gilchrist, Mark
Roberts, Jason A
Hope, William W
Holmes, Alison H
author_sort Rawson, Timothy M
collection PubMed
description This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.
format Online
Article
Text
id pubmed-8684501
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-86845012021-12-20 Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study Rawson, Timothy M Wilson, Richard C Moore, Luke S P Macgowan, Alasdair P Lovering, Andrew M Bayliss, Mark Kyriakides, Mathew Gilchrist, Mark Roberts, Jason A Hope, William W Holmes, Alison H Open Forum Infect Dis Brief Reports This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data. Oxford University Press 2021-12-18 /pmc/articles/PMC8684501/ /pubmed/34934774 http://dx.doi.org/10.1093/ofid/ofab573 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Rawson, Timothy M
Wilson, Richard C
Moore, Luke S P
Macgowan, Alasdair P
Lovering, Andrew M
Bayliss, Mark
Kyriakides, Mathew
Gilchrist, Mark
Roberts, Jason A
Hope, William W
Holmes, Alison H
Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title_full Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title_fullStr Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title_full_unstemmed Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title_short Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study
title_sort exploring the pharmacokinetics of phenoxymethylpenicillin (penicillin-v) in adults: a healthy volunteer study
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684501/
https://www.ncbi.nlm.nih.gov/pubmed/34934774
http://dx.doi.org/10.1093/ofid/ofab573
work_keys_str_mv AT rawsontimothym exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT wilsonrichardc exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT moorelukesp exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT macgowanalasdairp exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT loveringandrewm exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT baylissmark exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT kyriakidesmathew exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT gilchristmark exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT robertsjasona exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT hopewilliamw exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy
AT holmesalisonh exploringthepharmacokineticsofphenoxymethylpenicillinpenicillinvinadultsahealthyvolunteerstudy

Ejemplares similares