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Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

PURPOSE: To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? METHODS: After an electronic data se...

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Autores principales: Al-Maawi, Sarah, Becker, Kathrin, Schwarz, Frank, Sader, Robert, Ghanaati, Shahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684569/
https://www.ncbi.nlm.nih.gov/pubmed/34923613
http://dx.doi.org/10.1186/s40729-021-00393-0
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author Al-Maawi, Sarah
Becker, Kathrin
Schwarz, Frank
Sader, Robert
Ghanaati, Shahram
author_facet Al-Maawi, Sarah
Becker, Kathrin
Schwarz, Frank
Sader, Robert
Ghanaati, Shahram
author_sort Al-Maawi, Sarah
collection PubMed
description PURPOSE: To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? METHODS: After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. RESULTS: 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. CONCLUSIONS: Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
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spelling pubmed-86845692022-01-04 Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review Al-Maawi, Sarah Becker, Kathrin Schwarz, Frank Sader, Robert Ghanaati, Shahram Int J Implant Dent Review PURPOSE: To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? METHODS: After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. RESULTS: 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. CONCLUSIONS: Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed. Springer Berlin Heidelberg 2021-12-19 /pmc/articles/PMC8684569/ /pubmed/34923613 http://dx.doi.org/10.1186/s40729-021-00393-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Al-Maawi, Sarah
Becker, Kathrin
Schwarz, Frank
Sader, Robert
Ghanaati, Shahram
Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title_full Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title_fullStr Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title_full_unstemmed Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title_short Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
title_sort efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684569/
https://www.ncbi.nlm.nih.gov/pubmed/34923613
http://dx.doi.org/10.1186/s40729-021-00393-0
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