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Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection

BACKGROUND: Spinal cord stroke after coronavirus disease 19 (COVID-19) infection is rare, and limited cases have been reported. Spinal cord ischemia after COVID-19 infection is related to increased coagulopathy with thromboembolic consequences. Patients with COVID-19 may have a hypercoagulable state...

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Autor principal: Amalia, Lisda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684605/
https://www.ncbi.nlm.nih.gov/pubmed/34934376
http://dx.doi.org/10.2147/JBM.S329449
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author Amalia, Lisda
author_facet Amalia, Lisda
author_sort Amalia, Lisda
collection PubMed
description BACKGROUND: Spinal cord stroke after coronavirus disease 19 (COVID-19) infection is rare, and limited cases have been reported. Spinal cord ischemia after COVID-19 infection is related to increased coagulopathy with thromboembolic consequences. Patients with COVID-19 may have a hypercoagulable state and an increased rate of thromboembolic events, such as occlusion in the spinal artery. CASE PRESENTATION: We report a male case with confirmed COVID-19 infection, aged 60 years, with flaccid paraplegia, hyporeflexia, loss of sensation below the 12th thoracic level, loss of autonomic function, bilateral positive Babinski sign 14 days after the onset of flu-like symptoms, and elevated serum D-dimer and fibrinogen levels. There was stenosis of the spinal artery at the 12th thoracic level in magnetic resonance imaging and magnetic resonance angiography. He showed improvement in motor strength of the lower limb (walking with assistance), numbness and pain, and urine and fecal retention after receiving a subcutaneous anticoagulant. CONCLUSION: COVID-19 can damage endothelial cells and activate thrombotic pathways, which can lead to clinical thromboembolic complications, such as occlusion in the spinal artery, resulting in spinal cord stroke.
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spelling pubmed-86846052021-12-20 Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection Amalia, Lisda J Blood Med Case Report BACKGROUND: Spinal cord stroke after coronavirus disease 19 (COVID-19) infection is rare, and limited cases have been reported. Spinal cord ischemia after COVID-19 infection is related to increased coagulopathy with thromboembolic consequences. Patients with COVID-19 may have a hypercoagulable state and an increased rate of thromboembolic events, such as occlusion in the spinal artery. CASE PRESENTATION: We report a male case with confirmed COVID-19 infection, aged 60 years, with flaccid paraplegia, hyporeflexia, loss of sensation below the 12th thoracic level, loss of autonomic function, bilateral positive Babinski sign 14 days after the onset of flu-like symptoms, and elevated serum D-dimer and fibrinogen levels. There was stenosis of the spinal artery at the 12th thoracic level in magnetic resonance imaging and magnetic resonance angiography. He showed improvement in motor strength of the lower limb (walking with assistance), numbness and pain, and urine and fecal retention after receiving a subcutaneous anticoagulant. CONCLUSION: COVID-19 can damage endothelial cells and activate thrombotic pathways, which can lead to clinical thromboembolic complications, such as occlusion in the spinal artery, resulting in spinal cord stroke. Dove 2021-12-14 /pmc/articles/PMC8684605/ /pubmed/34934376 http://dx.doi.org/10.2147/JBM.S329449 Text en © 2021 Amalia. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Amalia, Lisda
Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title_full Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title_fullStr Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title_full_unstemmed Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title_short Hypercoagulable State Induced Spinal Cord Stroke After Coronavirus Disease 19 Infection
title_sort hypercoagulable state induced spinal cord stroke after coronavirus disease 19 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684605/
https://www.ncbi.nlm.nih.gov/pubmed/34934376
http://dx.doi.org/10.2147/JBM.S329449
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