Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation

Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear. In the current study, the role of Zoledronic acid (ZA),...

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Detalles Bibliográficos
Autores principales: Qu, Xingzhou, Sun, Zhaoqi, Wang, Yang, Ong, Hui Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684721/
https://www.ncbi.nlm.nih.gov/pubmed/35003915
http://dx.doi.org/10.7717/peerj.12510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684721/
https://www.ncbi.nlm.nih.gov/pubmed/35003915
http://dx.doi.org/10.7717/peerj.12510

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