Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila

Dilated cardiomyopathy (DCM), a life-threatening disease characterized by pathological heart enlargement, can be caused by myosin mutations that reduce contractile function. To better define the mechanistic basis of this disease, we employed the powerful genetic and integrative approaches available...

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Detalles Bibliográficos
Autores principales: Trujillo, Adriana S., Hsu, Karen H., Puthawala, Joy, Viswanathan, Meera C., Loya, Amy, Irving, Thomas C., Cammarato, Anthony, Swank, Douglas M., Bernstein, Sanford I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684735/
https://www.ncbi.nlm.nih.gov/pubmed/34081531
http://dx.doi.org/10.1091/mbc.E21-02-0088

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