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A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding

Dilated cardiomyopathy (DCM) is a significant cause of pediatric heart failure. Mutations in proteins that regulate cardiac muscle contraction can cause DCM; however, the mechanisms by which molecular-level mutations contribute to cellular dysfunction are not well understood. Better understanding of...

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Detalles Bibliográficos
Autores principales:	Barrick, Samantha K., Greenberg, Lina, Greenberg, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684737/ https://www.ncbi.nlm.nih.gov/pubmed/34161147 http://dx.doi.org/10.1091/mbc.E21-02-0082

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