A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome

Hypercalcemia of malignancy is relatively common in several cancers. However, in testicular cancer, paraneoplastic hypercalcemia is uncommon. We describe the first case of severe tumor lysis syndrome associated with hypercalcemia from bone metastasis of testicular origin. Classically, tumor lysis sy...

Descripción completa

Detalles Bibliográficos
Autores principales: Veeraballi, Sindhusha, Kumanayaka, Dilesha D, Omour, Bader, Paige, Amy, Shaaban, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684799/
https://www.ncbi.nlm.nih.gov/pubmed/34938626
http://dx.doi.org/10.7759/cureus.19749
_version_ 1784617695076941824
author Veeraballi, Sindhusha
Kumanayaka, Dilesha D
Omour, Bader
Paige, Amy
Shaaban, Hamid
author_facet Veeraballi, Sindhusha
Kumanayaka, Dilesha D
Omour, Bader
Paige, Amy
Shaaban, Hamid
author_sort Veeraballi, Sindhusha
collection PubMed
description Hypercalcemia of malignancy is relatively common in several cancers. However, in testicular cancer, paraneoplastic hypercalcemia is uncommon. We describe the first case of severe tumor lysis syndrome associated with hypercalcemia from bone metastasis of testicular origin. Classically, tumor lysis syndrome is associated with hypocalcemia. This was a diagnostic and therapeutic challenge. 
format Online
Article
Text
id pubmed-8684799
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-86847992021-12-21 A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome Veeraballi, Sindhusha Kumanayaka, Dilesha D Omour, Bader Paige, Amy Shaaban, Hamid Cureus Internal Medicine Hypercalcemia of malignancy is relatively common in several cancers. However, in testicular cancer, paraneoplastic hypercalcemia is uncommon. We describe the first case of severe tumor lysis syndrome associated with hypercalcemia from bone metastasis of testicular origin. Classically, tumor lysis syndrome is associated with hypocalcemia. This was a diagnostic and therapeutic challenge.  Cureus 2021-11-19 /pmc/articles/PMC8684799/ /pubmed/34938626 http://dx.doi.org/10.7759/cureus.19749 Text en Copyright © 2021, Veeraballi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Veeraballi, Sindhusha
Kumanayaka, Dilesha D
Omour, Bader
Paige, Amy
Shaaban, Hamid
A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title_full A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title_fullStr A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title_full_unstemmed A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title_short A Rare Case of Sarcomatoid Variant of Mixed Germ Cell Tumor of the Testis Presenting With Malignant Hypercalcemia and Tumor Lysis Syndrome
title_sort rare case of sarcomatoid variant of mixed germ cell tumor of the testis presenting with malignant hypercalcemia and tumor lysis syndrome
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684799/
https://www.ncbi.nlm.nih.gov/pubmed/34938626
http://dx.doi.org/10.7759/cureus.19749
work_keys_str_mv AT veeraballisindhusha ararecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT kumanayakadileshad ararecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT omourbader ararecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT paigeamy ararecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT shaabanhamid ararecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT veeraballisindhusha rarecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT kumanayakadileshad rarecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT omourbader rarecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT paigeamy rarecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome
AT shaabanhamid rarecaseofsarcomatoidvariantofmixedgermcelltumorofthetestispresentingwithmalignanthypercalcemiaandtumorlysissyndrome

Ejemplares similares