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Time to Align: A Call for Consensus on the Assessment of Genetic Testing
In this paper, we updated our 2018 systematic review aimed to identify and compare ad hoc designed frameworks for genetic testing evaluation. Overall, we identified 30 frameworks (29 in the first systematic review and one in the update): they were mainly based on the ACCE model, whereas a minority w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685239/ https://www.ncbi.nlm.nih.gov/pubmed/34938716 http://dx.doi.org/10.3389/fpubh.2021.807695 |
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author | Pitini, Erica Baccolini, Valentina Migliara, Giuseppe Isonne, Claudia Sindoni, Alessandro Mazzalai, Elena Turatto, Federica De Vito, Corrado Marzuillo, Carolina Villari, Paolo |
author_facet | Pitini, Erica Baccolini, Valentina Migliara, Giuseppe Isonne, Claudia Sindoni, Alessandro Mazzalai, Elena Turatto, Federica De Vito, Corrado Marzuillo, Carolina Villari, Paolo |
author_sort | Pitini, Erica |
collection | PubMed |
description | In this paper, we updated our 2018 systematic review aimed to identify and compare ad hoc designed frameworks for genetic testing evaluation. Overall, we identified 30 frameworks (29 in the first systematic review and one in the update): they were mainly based on the ACCE model, whereas a minority were adjustments of the more traditional Health Technology Assessment (HTA) approach. After discussing the strengths and weaknesses of the retrieved frameworks, this perspective calls for consensus on the assessment of genetic testing. In line with the recent European recommendations that encouraged the generation of comparable evidence across Member States, we believe that the time has come to align all the ideas that have emerged over the last few decades and find a sustainable and sharable tool for the evaluation of genetic and genomic applications. Therefore, we suggest stopping the evaluation of such technologies using ad hoc strategies–affected by validation, implementation, and adoption issues–and we propose to use a general HTA approach, particularly the European reference tool for the assessment of health technologies, the EUnetHTA HTA core model, that is built on solid theoretical and methodological principles and provides a comprehensive assessment of the technologies value. |
format | Online Article Text |
id | pubmed-8685239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86852392021-12-21 Time to Align: A Call for Consensus on the Assessment of Genetic Testing Pitini, Erica Baccolini, Valentina Migliara, Giuseppe Isonne, Claudia Sindoni, Alessandro Mazzalai, Elena Turatto, Federica De Vito, Corrado Marzuillo, Carolina Villari, Paolo Front Public Health Public Health In this paper, we updated our 2018 systematic review aimed to identify and compare ad hoc designed frameworks for genetic testing evaluation. Overall, we identified 30 frameworks (29 in the first systematic review and one in the update): they were mainly based on the ACCE model, whereas a minority were adjustments of the more traditional Health Technology Assessment (HTA) approach. After discussing the strengths and weaknesses of the retrieved frameworks, this perspective calls for consensus on the assessment of genetic testing. In line with the recent European recommendations that encouraged the generation of comparable evidence across Member States, we believe that the time has come to align all the ideas that have emerged over the last few decades and find a sustainable and sharable tool for the evaluation of genetic and genomic applications. Therefore, we suggest stopping the evaluation of such technologies using ad hoc strategies–affected by validation, implementation, and adoption issues–and we propose to use a general HTA approach, particularly the European reference tool for the assessment of health technologies, the EUnetHTA HTA core model, that is built on solid theoretical and methodological principles and provides a comprehensive assessment of the technologies value. Frontiers Media S.A. 2021-12-06 /pmc/articles/PMC8685239/ /pubmed/34938716 http://dx.doi.org/10.3389/fpubh.2021.807695 Text en Copyright © 2021 Pitini, Baccolini, Migliara, Isonne, Sindoni, Mazzalai, Turatto, De Vito, Marzuillo and Villari. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Pitini, Erica Baccolini, Valentina Migliara, Giuseppe Isonne, Claudia Sindoni, Alessandro Mazzalai, Elena Turatto, Federica De Vito, Corrado Marzuillo, Carolina Villari, Paolo Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title | Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title_full | Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title_fullStr | Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title_full_unstemmed | Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title_short | Time to Align: A Call for Consensus on the Assessment of Genetic Testing |
title_sort | time to align: a call for consensus on the assessment of genetic testing |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685239/ https://www.ncbi.nlm.nih.gov/pubmed/34938716 http://dx.doi.org/10.3389/fpubh.2021.807695 |
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