Cargando…

High Expression of BCL11A Predicts Poor Prognosis for Childhood MLL-r ALL

BACKGROUND: Despite much improvement in the treatment for acute lymphoblastic leukemia (ALL), childhood ALLs with MLL-rearrangement (MLL-r) still have inferior dismal prognosis. Thus, defining mechanisms underlying MLL-r ALL maintenance is critical for developing effective therapy. METHODS: GSE13159...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lu-Lu, Yan, Dehong, Tang, Xue, Zhang, Mengqi, Liu, Shilin, Wang, Ying, Zhang, Min, Zhou, Guichi, Li, Tonghui, Jiang, Feifei, Chen, Xiaowen, Wen, Feiqiu, Liu, Sixi, Mai, Huirong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685382/ https://www.ncbi.nlm.nih.gov/pubmed/34938655 http://dx.doi.org/10.3389/fonc.2021.755188

Ejemplares similares

PROM1 and CTGF Expression in Childhood MLL-Rearrangement Acute Lymphoblastic Leukemia
por: Wang, Lu-lu, et al.
Publicado: (2022)

Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia
por: Li, Yue, et al.
Publicado: (2017)

Resistance genomics and molecular epidemiology of high-risk clones of ESBL-producing Pseudomonas aeruginosa in young children
por: Patil, Sandip, et al.
Publicado: (2023)

Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia
por: Li, Yuhua, et al.
Publicado: (2017)

LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
por: Fang, Ximin, et al.
Publicado: (2021)

Successful outcome of disseminated Candida tropicalis osteomyelitis on remission induction for childhood Philadelphia chromosome–positive acute lymphoblastic leukaemia-case report
por: Xie, Lichun, et al.
Publicado: (2021)

HucMSC exosomes promoted imatinib-induced apoptosis in K562-R cells via a miR-145a-5p/USP6/GLS1 axis
por: Chen, Xiaowen, et al.
Publicado: (2022)

Trends in Antibiotic Resistance Patterns and Burden of Escherichia Coli Infections in Young Children: A Retrospective Cross-Sectional Study in Shenzhen, China from 2014–2018
por: Patil, Sandip, et al.
Publicado: (2023)

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
por: Hurtz, Christian, et al.
Publicado: (2019)

Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - induced by hypersensitivity
por: Dai, Dongling, et al.
Publicado: (2016)

Methylation of CDKN2B CpG islands is associated with upregulated telomerase activity in children with acute lymphoblastic leukemia
por: Hu, Qian, et al.
Publicado: (2017)

Developing an Unbiased Multiplex PCR System to Enrich the TRB Repertoire Toward Accurate Detection in Leukemia
por: Wu, Jinghua, et al.
Publicado: (2020)

Recent advances in engineering hydrogels for niche biomimicking and hematopoietic stem cell culturing
por: Huang, Xiaochan, et al.
Publicado: (2022)

Evaluation of the vitamin D and biomedical statuses of young children with β-thalassemia major at a single center in southern China
por: Yu, Uet, et al.
Publicado: (2019)

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95
por: Jiang, Hao, et al.
Publicado: (2013)

Minimal Residual Disease Detection and Evolved IGH Clones Analysis in Acute B Lymphoblastic Leukemia Using IGH Deep Sequencing
por: Wu, Jinghua, et al.
Publicado: (2016)

Massive hydatid cysts in the lung and liver of a 4‐year‐old boy
por: Yu, Uet, et al.
Publicado: (2020)

Klebsiella pneumoniae infection in the paediatric population before and after the COVID-19 pandemic in Shenzhen, China
por: Patil, Sandip, et al.
Publicado: (2023)

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
por: Xu, Jing, et al.
Publicado: (2016)

Novel Pseudomonas aeruginosa Strains Co-Harbouring bla(NDM-1) Metallo β-Lactamase and mcr-1 Isolated from Immunocompromised Paediatric Patients
por: Chen, Hongyu, et al.
Publicado: (2022)

WNT974 Inhibits Proliferation, Induces Apoptosis, and Enhances Chemosensitivity to Doxorubicin in Lymphoma Cells by Inhibiting Wnt/β-Catenin Signaling
por: Chen, Senmin, et al.
Publicado: (2020)

Retracted: WNT974 Inhibits Proliferation, Induces Apoptosis, and Enhances Chemosensitivity to Doxorubicin in Lymphoma Cells by Inhibiting Wnt/β-Catenin Signaling
por: Chen, Senmin, et al.
Publicado: (2023)

Cytomegalovirus (CMV)-specific cytotoxic T lymphocyte therapy resolve CMV diseases and refractory CMV infections in paediatric recipients of allogeneic haematopoietic stem cell transplantation
por: Wang, Xiaodong, et al.
Publicado: (2021)

Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance
por: Sun, Chi, et al.
Publicado: (2022)

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
por: Benito, Juliana M., et al.
Publicado: (2015)

High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma
por: Abudureheman, Abulajiang, et al.
Publicado: (2018)

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice
por: Anstee, Natasha S., et al.
Publicado: (2018)

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
por: Liu, Y, et al.
Publicado: (2014)

Co-Transplantation of Haploidentical Stem Cells and a Dose of Unrelated Cord Blood in Pediatric Patients with Thalassemia Major
por: Wang, Xiaodong, et al.
Publicado: (2021)

Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients
por: Zhang, Xiao-Fei, et al.
Publicado: (2016)

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)
por: Sun, Q-Y, et al.
Publicado: (2017)

Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia
por: Xing, Zhihao, et al.
Publicado: (2022)

Effect of lead exposure from electronic waste on haemoglobin synthesis in children
por: Wang, Hongwu, et al.
Publicado: (2021)

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation
por: Godfrey, Laura, et al.
Publicado: (2017)

P2X7 promotes the progression of MLL-AF9-induced acute myeloid leukemia by upregulation of Pbx3
por: Feng, Wenli, et al.
Publicado: (2020)

A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition
por: Soto-Feliciano, Yadira M., et al.
Publicado: (2023)

Erratum to Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients
por: Zhang, Xiao-Fei, et al.
Publicado: (2017)

Successful Treatment of Rare Pulmonary Coprinopsis cinerea Infection in a 17-Year-Old Female After Hematopoietic Stem Cell Transplantation: A Case Report
por: Yu, Uet, et al.
Publicado: (2023)

Acute Myeloid Leukemia Cells Harboring MLL Fusion Genes or with the Acute Promyelocytic Leukemia Phenotype Are Sensitive to the Bcl-2-selective Inhibitor ABT-199
por: Niu, Xiaojia, et al.
Publicado: (2014)

DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells
por: Li, Weijing, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k5sk3gp9asu1n7fhrf4j4jukaa