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ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demo...

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Detalles Bibliográficos
Autores principales: Neyrinck-Leglantier, Déborah, Lesage, Julien, Blacher, Silvia, Bonnomet, Arnaud, Hunziker, Walter, Noël, Agnès, Dormoy, Valérian, Nawrocki-Raby, Béatrice, Gilles, Christine, Polette, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685499/
https://www.ncbi.nlm.nih.gov/pubmed/34938731
http://dx.doi.org/10.3389/fcell.2021.749364
Descripción
Sumario:Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.