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Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study

Background and Purpose: End-stage renal disease (ESRD) results in extensive white matter abnormalities, but the specific damage segment cannot be identified. This study aimed to determine the segmental abnormalities of white matter microstructure in ESRD and its relationship with cognitive and renal...

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Autores principales: Jiang, Yuhan, Liu, Yangyingqiu, Gao, Bingbing, Che, Yiwei, Lin, Liangjie, Jiang, Jian, Chang, Peipei, Song, Qingwei, Wang, Nan, Wang, Weiwei, Miao, Yanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685541/
https://www.ncbi.nlm.nih.gov/pubmed/34938154
http://dx.doi.org/10.3389/fnins.2021.765677
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author Jiang, Yuhan
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Nan
Wang, Weiwei
Miao, Yanwei
author_facet Jiang, Yuhan
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Nan
Wang, Weiwei
Miao, Yanwei
author_sort Jiang, Yuhan
collection PubMed
description Background and Purpose: End-stage renal disease (ESRD) results in extensive white matter abnormalities, but the specific damage segment cannot be identified. This study aimed to determine the segmental abnormalities of white matter microstructure in ESRD and its relationship with cognitive and renal function indicators. Methods: Eighteen ESRD patients and 19 healthy controls (HCs) were prospectively recruited. All participants underwent DTI and clinical assessments. Automatic fiber quantification (AFQ) was applied to generate bundle profiles along 16 main white matter tracts. We compared the DTI parameters between groups. Besides, we used partial correlation and multiple linear regression analyses to explore the associations between white matter integrity and cognitive performance as well as renal function indicators. Results: In the global tract level, compared to HCs, ESRD patients had greater MD, AD, and RD values and lower FA value in several fibers (P < 0.05, FDR correction). In the point-wise level, extensive damage existed in specific locations of different fiber tracts, particularly in the left hemisphere (P < 0.05, FDR correction). Among these tracts, the mean AD values of the left cingulum cingulate correlated negatively with MoCA score. Urea and UA level were independent predictors of the AD value of superior component of the left corticospinal. Besides, urea level was the independent predictors of mean MD value of left anterior thalamic radiation (ATR). Conclusion: White matter fiber tract damage in ESRD patients may be characterized by abnormalities in its specific location, especially in the left hemisphere. Aberrational specific located fibers were related to cognitive impairment and renal dysfunction.
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spelling pubmed-86855412021-12-21 Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study Jiang, Yuhan Liu, Yangyingqiu Gao, Bingbing Che, Yiwei Lin, Liangjie Jiang, Jian Chang, Peipei Song, Qingwei Wang, Nan Wang, Weiwei Miao, Yanwei Front Neurosci Neuroscience Background and Purpose: End-stage renal disease (ESRD) results in extensive white matter abnormalities, but the specific damage segment cannot be identified. This study aimed to determine the segmental abnormalities of white matter microstructure in ESRD and its relationship with cognitive and renal function indicators. Methods: Eighteen ESRD patients and 19 healthy controls (HCs) were prospectively recruited. All participants underwent DTI and clinical assessments. Automatic fiber quantification (AFQ) was applied to generate bundle profiles along 16 main white matter tracts. We compared the DTI parameters between groups. Besides, we used partial correlation and multiple linear regression analyses to explore the associations between white matter integrity and cognitive performance as well as renal function indicators. Results: In the global tract level, compared to HCs, ESRD patients had greater MD, AD, and RD values and lower FA value in several fibers (P < 0.05, FDR correction). In the point-wise level, extensive damage existed in specific locations of different fiber tracts, particularly in the left hemisphere (P < 0.05, FDR correction). Among these tracts, the mean AD values of the left cingulum cingulate correlated negatively with MoCA score. Urea and UA level were independent predictors of the AD value of superior component of the left corticospinal. Besides, urea level was the independent predictors of mean MD value of left anterior thalamic radiation (ATR). Conclusion: White matter fiber tract damage in ESRD patients may be characterized by abnormalities in its specific location, especially in the left hemisphere. Aberrational specific located fibers were related to cognitive impairment and renal dysfunction. Frontiers Media S.A. 2021-12-06 /pmc/articles/PMC8685541/ /pubmed/34938154 http://dx.doi.org/10.3389/fnins.2021.765677 Text en Copyright © 2021 Jiang, Liu, Gao, Che, Lin, Jiang, Chang, Song, Wang, Wang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jiang, Yuhan
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Nan
Wang, Weiwei
Miao, Yanwei
Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title_full Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title_fullStr Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title_full_unstemmed Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title_short Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study
title_sort segmental abnormalities of white matter microstructure in end-stage renal disease patients: an automated fiber quantification tractography study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685541/
https://www.ncbi.nlm.nih.gov/pubmed/34938154
http://dx.doi.org/10.3389/fnins.2021.765677
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