Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force micros...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Xiaoteng, Liu, Shuai, Wang, Xiuchao, Xia, Dan, Li, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685561/
https://www.ncbi.nlm.nih.gov/pubmed/34987950
http://dx.doi.org/10.3762/bjnano.12.101
_version_ 1784617859938254848
author Liang, Xiaoteng
Liu, Shuai
Wang, Xiuchao
Xia, Dan
Li, Qiang
author_facet Liang, Xiaoteng
Liu, Shuai
Wang, Xiuchao
Xia, Dan
Li, Qiang
author_sort Liang, Xiaoteng
collection PubMed
description The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells.
format Online
Article
Text
id pubmed-8685561
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-86855612022-01-04 Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy Liang, Xiaoteng Liu, Shuai Wang, Xiuchao Xia, Dan Li, Qiang Beilstein J Nanotechnol Full Research Paper The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells. Beilstein-Institut 2021-12-14 /pmc/articles/PMC8685561/ /pubmed/34987950 http://dx.doi.org/10.3762/bjnano.12.101 Text en Copyright © 2021, Liang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Liang, Xiaoteng
Liu, Shuai
Wang, Xiuchao
Xia, Dan
Li, Qiang
Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title_full Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title_fullStr Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title_full_unstemmed Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title_short Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
title_sort alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685561/
https://www.ncbi.nlm.nih.gov/pubmed/34987950
http://dx.doi.org/10.3762/bjnano.12.101
work_keys_str_mv AT liangxiaoteng alterationofnanomechanicalpropertiesofpancreaticcancercellsthroughanticancerdrugtreatmentrevealedbyatomicforcemicroscopy
AT liushuai alterationofnanomechanicalpropertiesofpancreaticcancercellsthroughanticancerdrugtreatmentrevealedbyatomicforcemicroscopy
AT wangxiuchao alterationofnanomechanicalpropertiesofpancreaticcancercellsthroughanticancerdrugtreatmentrevealedbyatomicforcemicroscopy
AT xiadan alterationofnanomechanicalpropertiesofpancreaticcancercellsthroughanticancerdrugtreatmentrevealedbyatomicforcemicroscopy
AT liqiang alterationofnanomechanicalpropertiesofpancreaticcancercellsthroughanticancerdrugtreatmentrevealedbyatomicforcemicroscopy

Ejemplares similares