Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with...

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Detalles Bibliográficos
Autores principales: van Oort, Pouline MP, Nijsen, Tamara M, White, Iain R, Knobel, Hugo H, Felton, Timothy, Rattray, Nicholas, Lawal, Oluwasola, Bulut, Murtaza, Ahmed, Waqar, Artigas, Antonio, Povoa, Pedro R, Martin-Loeches, Ignacio, Weda, Hans, Goodacre, Royston, Schultz, Marcus J, Dark, Paul M, Fowler, Stephen J, Bos, Lieuwe D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685633/
https://www.ncbi.nlm.nih.gov/pubmed/34088787
http://dx.doi.org/10.1136/thoraxjnl-2021-217362
Descripción
Sumario:Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.

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