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Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pres...

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Autores principales: Chen, Kexin, Zeng, Zhen, Ma, Chunxiang, Dang, Yuan, Zhang, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685636/
https://www.ncbi.nlm.nih.gov/pubmed/34850851
http://dx.doi.org/10.1042/BSR20211096
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author Chen, Kexin
Zeng, Zhen
Ma, Chunxiang
Dang, Yuan
Zhang, Hu
author_facet Chen, Kexin
Zeng, Zhen
Ma, Chunxiang
Dang, Yuan
Zhang, Hu
author_sort Chen, Kexin
collection PubMed
description Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pressing need to explore novel therapeutic targets of COAD. Available evidence indicated that immune cell infiltration was correlated with cancer prognosis. To reveal the roles of immune cells in the COAD prognosis, a study published in Bioscience Reports by Li et al. (Bioscience Reports (2021) 41, https://doi.org/10.1042/BSR20203496) analyzed data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset. It demonstrated a beneficial effect of Th17 cells in COAD prognosis. In addition, six hub genes (KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, and SLC28A2) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further.
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spelling pubmed-86856362021-12-21 Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers Chen, Kexin Zeng, Zhen Ma, Chunxiang Dang, Yuan Zhang, Hu Biosci Rep Cancer Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pressing need to explore novel therapeutic targets of COAD. Available evidence indicated that immune cell infiltration was correlated with cancer prognosis. To reveal the roles of immune cells in the COAD prognosis, a study published in Bioscience Reports by Li et al. (Bioscience Reports (2021) 41, https://doi.org/10.1042/BSR20203496) analyzed data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset. It demonstrated a beneficial effect of Th17 cells in COAD prognosis. In addition, six hub genes (KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, and SLC28A2) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further. Portland Press Ltd. 2021-12-17 /pmc/articles/PMC8685636/ /pubmed/34850851 http://dx.doi.org/10.1042/BSR20211096 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cancer
Chen, Kexin
Zeng, Zhen
Ma, Chunxiang
Dang, Yuan
Zhang, Hu
Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title_full Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title_fullStr Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title_full_unstemmed Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title_short Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
title_sort commentary on: screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685636/
https://www.ncbi.nlm.nih.gov/pubmed/34850851
http://dx.doi.org/10.1042/BSR20211096
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