Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymph...

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Detalles Bibliográficos
Autores principales: Mitsuyama, Yumi, Yamakawa, Kazuma, Kayano, Katsuhide, Maruyama, Miho, Wada, Takeshi, Fujimi, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685802/
https://www.ncbi.nlm.nih.gov/pubmed/34930468
http://dx.doi.org/10.1186/s40560-021-00591-3
Descripción
Sumario:We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.

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