Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymph...

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Autores principales: Mitsuyama, Yumi, Yamakawa, Kazuma, Kayano, Katsuhide, Maruyama, Miho, Wada, Takeshi, Fujimi, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685802/
https://www.ncbi.nlm.nih.gov/pubmed/34930468
http://dx.doi.org/10.1186/s40560-021-00591-3
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author Mitsuyama, Yumi
Yamakawa, Kazuma
Kayano, Katsuhide
Maruyama, Miho
Wada, Takeshi
Fujimi, Satoshi
author_facet Mitsuyama, Yumi
Yamakawa, Kazuma
Kayano, Katsuhide
Maruyama, Miho
Wada, Takeshi
Fujimi, Satoshi
author_sort Mitsuyama, Yumi
collection PubMed
description We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.
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spelling pubmed-86858022021-12-20 Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19 Mitsuyama, Yumi Yamakawa, Kazuma Kayano, Katsuhide Maruyama, Miho Wada, Takeshi Fujimi, Satoshi J Intensive Care Letter to the Editor We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19. BioMed Central 2021-12-20 /pmc/articles/PMC8685802/ /pubmed/34930468 http://dx.doi.org/10.1186/s40560-021-00591-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Mitsuyama, Yumi
Yamakawa, Kazuma
Kayano, Katsuhide
Maruyama, Miho
Wada, Takeshi
Fujimi, Satoshi
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title_full Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title_fullStr Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title_full_unstemmed Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title_short Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
title_sort prolonged enhancement of cytotoxic t lymphocytes in the post-recovery state of severe covid-19
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685802/
https://www.ncbi.nlm.nih.gov/pubmed/34930468
http://dx.doi.org/10.1186/s40560-021-00591-3
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