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DCLK1 autoinhibition and activation in tumorigenesis

Doublecortin-like kinase 1 (DCLK1) is upregulated in many tumors and is a marker for tumor stem cells. Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy. However, the regulation of DCLK1 kinase activity is poorly understood, particularly the function of its...

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Detalles Bibliográficos
Autores principales:	Cheng, Linna, Yang, Zejing, Guo, Wenhao, Wu, Chengyong, Liang, Shufang, Tong, Aiping, Cao, Zhongwei, Thorne, Rick F., Yang, Sheng-Yong, Yu, Yamei, Chen, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686072/ https://www.ncbi.nlm.nih.gov/pubmed/34977835 http://dx.doi.org/10.1016/j.xinn.2021.100191

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