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Dissociation and Brain Rhythms: Pitfalls and Promises
Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686110/ https://www.ncbi.nlm.nih.gov/pubmed/34938216 http://dx.doi.org/10.3389/fpsyt.2021.790372 |
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author | Grent-'t-Jong, Tineke Melloni, Lucia Uhlhaas, Peter J. |
author_facet | Grent-'t-Jong, Tineke Melloni, Lucia Uhlhaas, Peter J. |
author_sort | Grent-'t-Jong, Tineke |
collection | PubMed |
description | Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms. |
format | Online Article Text |
id | pubmed-8686110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86861102021-12-21 Dissociation and Brain Rhythms: Pitfalls and Promises Grent-'t-Jong, Tineke Melloni, Lucia Uhlhaas, Peter J. Front Psychiatry Psychiatry Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms. Frontiers Media S.A. 2021-12-03 /pmc/articles/PMC8686110/ /pubmed/34938216 http://dx.doi.org/10.3389/fpsyt.2021.790372 Text en Copyright © 2021 Grent-'t-Jong, Melloni and Uhlhaas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Grent-'t-Jong, Tineke Melloni, Lucia Uhlhaas, Peter J. Dissociation and Brain Rhythms: Pitfalls and Promises |
title | Dissociation and Brain Rhythms: Pitfalls and Promises |
title_full | Dissociation and Brain Rhythms: Pitfalls and Promises |
title_fullStr | Dissociation and Brain Rhythms: Pitfalls and Promises |
title_full_unstemmed | Dissociation and Brain Rhythms: Pitfalls and Promises |
title_short | Dissociation and Brain Rhythms: Pitfalls and Promises |
title_sort | dissociation and brain rhythms: pitfalls and promises |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686110/ https://www.ncbi.nlm.nih.gov/pubmed/34938216 http://dx.doi.org/10.3389/fpsyt.2021.790372 |
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