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Clinical features and survival of patients with multiple primary malignancies

BACKGROUND: Multiple primary malignancies (MPM) are characterized by two or more primary malignancies in the same patient, excluding relapse or metastasis of prior cancer. We aimed to elucidate the clinical features and survival of MPM patients. AIM: To elucidate the clinical features and survival o...

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Autores principales: Wang, Xin-Kun, Zhou, Min-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686159/
https://www.ncbi.nlm.nih.gov/pubmed/35004980
http://dx.doi.org/10.12998/wjcc.v9.i34.10484
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author Wang, Xin-Kun
Zhou, Min-Hang
author_facet Wang, Xin-Kun
Zhou, Min-Hang
author_sort Wang, Xin-Kun
collection PubMed
description BACKGROUND: Multiple primary malignancies (MPM) are characterized by two or more primary malignancies in the same patient, excluding relapse or metastasis of prior cancer. We aimed to elucidate the clinical features and survival of MPM patients. AIM: To elucidate the clinical features and survival of MPM patients. METHODS: A retrospective study of MPM patients was conducted in our hospital between June 2016 and June 2019. Overall survival (OS) was calculated using the Kaplan-Meier method. The log-rank test was used to compare the survival of different groups. RESULTS: A total of 243 MPM patients were enrolled, including 222 patients with two malignancies and 21 patients with three malignancies. Of patients with two malignancies, 51 (23.0%) had synchronous MPM, and 171 (77.7%) had metachronous MPM. The most common first cancers were breast cancer (33, 14.9%) and colorectal cancer (31, 14.0%). The most common second cancers were non-small cell lung cancer (NSCLC) (66, 29.7%) and gastric cancer (24, 10.8%). There was no survival difference between synchronous and metachronous MPM patients (36.4 vs 35.3 mo, P = 0.809). Patients aged > 65 years at diagnosis of the second cancer had a shorter survival than patients ≤ 65 years (28.4 vs 36.4 mo, P = 0.038). Patients with distant metastasis had worse survival than patients without metastasis (20.4 vs 86.9 mo, P = 0.000). Following multivariate analyses, age > 65 years and distant metastasis were independent adverse prognostic factors for OS. CONCLUSION: During follow-up of a first cancer, the occurrence of a second or more cancers should receive greater attention, especially for common concomitant MPM, to ensure early detection and treatment of the subsequent cancer.
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spelling pubmed-86861592022-01-06 Clinical features and survival of patients with multiple primary malignancies Wang, Xin-Kun Zhou, Min-Hang World J Clin Cases Retrospective Cohort Study BACKGROUND: Multiple primary malignancies (MPM) are characterized by two or more primary malignancies in the same patient, excluding relapse or metastasis of prior cancer. We aimed to elucidate the clinical features and survival of MPM patients. AIM: To elucidate the clinical features and survival of MPM patients. METHODS: A retrospective study of MPM patients was conducted in our hospital between June 2016 and June 2019. Overall survival (OS) was calculated using the Kaplan-Meier method. The log-rank test was used to compare the survival of different groups. RESULTS: A total of 243 MPM patients were enrolled, including 222 patients with two malignancies and 21 patients with three malignancies. Of patients with two malignancies, 51 (23.0%) had synchronous MPM, and 171 (77.7%) had metachronous MPM. The most common first cancers were breast cancer (33, 14.9%) and colorectal cancer (31, 14.0%). The most common second cancers were non-small cell lung cancer (NSCLC) (66, 29.7%) and gastric cancer (24, 10.8%). There was no survival difference between synchronous and metachronous MPM patients (36.4 vs 35.3 mo, P = 0.809). Patients aged > 65 years at diagnosis of the second cancer had a shorter survival than patients ≤ 65 years (28.4 vs 36.4 mo, P = 0.038). Patients with distant metastasis had worse survival than patients without metastasis (20.4 vs 86.9 mo, P = 0.000). Following multivariate analyses, age > 65 years and distant metastasis were independent adverse prognostic factors for OS. CONCLUSION: During follow-up of a first cancer, the occurrence of a second or more cancers should receive greater attention, especially for common concomitant MPM, to ensure early detection and treatment of the subsequent cancer. Baishideng Publishing Group Inc 2021-12-06 2021-12-06 /pmc/articles/PMC8686159/ /pubmed/35004980 http://dx.doi.org/10.12998/wjcc.v9.i34.10484 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Cohort Study
Wang, Xin-Kun
Zhou, Min-Hang
Clinical features and survival of patients with multiple primary malignancies
title Clinical features and survival of patients with multiple primary malignancies
title_full Clinical features and survival of patients with multiple primary malignancies
title_fullStr Clinical features and survival of patients with multiple primary malignancies
title_full_unstemmed Clinical features and survival of patients with multiple primary malignancies
title_short Clinical features and survival of patients with multiple primary malignancies
title_sort clinical features and survival of patients with multiple primary malignancies
topic Retrospective Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686159/
https://www.ncbi.nlm.nih.gov/pubmed/35004980
http://dx.doi.org/10.12998/wjcc.v9.i34.10484
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