Long non-coding RNA XIST: a novel oncogene in multiple cancers

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor on...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Qi, Manlong, Fei, Xiang, Wang, Xia, Wang, Kefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686246/
https://www.ncbi.nlm.nih.gov/pubmed/34930117
http://dx.doi.org/10.1186/s10020-021-00421-0
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author Yang, Jun
Qi, Manlong
Fei, Xiang
Wang, Xia
Wang, Kefeng
author_facet Yang, Jun
Qi, Manlong
Fei, Xiang
Wang, Xia
Wang, Kefeng
author_sort Yang, Jun
collection PubMed
description Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study.
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spelling pubmed-86862462021-12-20 Long non-coding RNA XIST: a novel oncogene in multiple cancers Yang, Jun Qi, Manlong Fei, Xiang Wang, Xia Wang, Kefeng Mol Med Review Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study. BioMed Central 2021-12-20 /pmc/articles/PMC8686246/ /pubmed/34930117 http://dx.doi.org/10.1186/s10020-021-00421-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Yang, Jun
Qi, Manlong
Fei, Xiang
Wang, Xia
Wang, Kefeng
Long non-coding RNA XIST: a novel oncogene in multiple cancers
title Long non-coding RNA XIST: a novel oncogene in multiple cancers
title_full Long non-coding RNA XIST: a novel oncogene in multiple cancers
title_fullStr Long non-coding RNA XIST: a novel oncogene in multiple cancers
title_full_unstemmed Long non-coding RNA XIST: a novel oncogene in multiple cancers
title_short Long non-coding RNA XIST: a novel oncogene in multiple cancers
title_sort long non-coding rna xist: a novel oncogene in multiple cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686246/
https://www.ncbi.nlm.nih.gov/pubmed/34930117
http://dx.doi.org/10.1186/s10020-021-00421-0
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AT wangkefeng longnoncodingrnaxistanoveloncogeneinmultiplecancers

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