3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway

BACKGROUND: Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, the roles of exosomes derived from human embryonic stem cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D) culture, the clinical and biological relevance...

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Detalles Bibliográficos
Autores principales: Wang, Ning, Li, Xiajing, Zhong, Zhiyong, Qiu, Yaqi, Liu, Shoupei, Wu, Haibin, Tang, Xianglian, Chen, Chuxin, Fu, Yingjie, Chen, Qicong, Guo, Tingting, Li, Jinsong, Zhang, Shuai, Zern, Mark A., Ma, Keqiang, Wang, Bailin, Ou, Yimeng, Gu, Weili, Cao, Jie, Chen, Honglin, Duan, Yuyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686281/
https://www.ncbi.nlm.nih.gov/pubmed/34930304
http://dx.doi.org/10.1186/s12951-021-01138-2

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