NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. NOX4 is a constitutively active enzyme that primarily produces hydroge...

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Autores principales: Bi, Yawei, Lei, Xiao, Chai, Ningli, Linghu, Enqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686284/
https://www.ncbi.nlm.nih.gov/pubmed/34930338
http://dx.doi.org/10.1186/s12967-021-03182-w
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author Bi, Yawei
Lei, Xiao
Chai, Ningli
Linghu, Enqiang
author_facet Bi, Yawei
Lei, Xiao
Chai, Ningli
Linghu, Enqiang
author_sort Bi, Yawei
collection PubMed
description Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. NOX4 is a constitutively active enzyme that primarily produces hydrogen peroxide, which exhibits completely different properties from other subtypes of NOX family. More importantly, recent studies illuminate that NOX4 promotes pancreatic cancer occurrence and development in different ways. This review summarizes the potential roles and its mechanism of NOX4 in pancreatic cancer and explores NOX4 as the potential therapeutic target in pancreatic cancer.
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spelling pubmed-86862842021-12-20 NOX4: a potential therapeutic target for pancreatic cancer and its mechanism Bi, Yawei Lei, Xiao Chai, Ningli Linghu, Enqiang J Transl Med Review Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. NOX4 is a constitutively active enzyme that primarily produces hydrogen peroxide, which exhibits completely different properties from other subtypes of NOX family. More importantly, recent studies illuminate that NOX4 promotes pancreatic cancer occurrence and development in different ways. This review summarizes the potential roles and its mechanism of NOX4 in pancreatic cancer and explores NOX4 as the potential therapeutic target in pancreatic cancer. BioMed Central 2021-12-20 /pmc/articles/PMC8686284/ /pubmed/34930338 http://dx.doi.org/10.1186/s12967-021-03182-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Bi, Yawei
Lei, Xiao
Chai, Ningli
Linghu, Enqiang
NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title_full NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title_fullStr NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title_full_unstemmed NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title_short NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
title_sort nox4: a potential therapeutic target for pancreatic cancer and its mechanism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686284/
https://www.ncbi.nlm.nih.gov/pubmed/34930338
http://dx.doi.org/10.1186/s12967-021-03182-w
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AT chainingli nox4apotentialtherapeutictargetforpancreaticcanceranditsmechanism
AT linghuenqiang nox4apotentialtherapeutictargetforpancreaticcanceranditsmechanism

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