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A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy

BACKGROUND: As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental exp...

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Autores principales: Hua, Yue, Wang, Yuan, Kang, Xue, Xu, Fan, Han, Zhen, Zhang, Chong, Wang, Zhao-Yang, Liu, Jun-Qi, Zhao, Xueli, Chen, Xiaoyuan, Zang, Shuang-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686291/
https://www.ncbi.nlm.nih.gov/pubmed/34930279
http://dx.doi.org/10.1186/s12951-021-01191-x
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author Hua, Yue
Wang, Yuan
Kang, Xue
Xu, Fan
Han, Zhen
Zhang, Chong
Wang, Zhao-Yang
Liu, Jun-Qi
Zhao, Xueli
Chen, Xiaoyuan
Zang, Shuang-Quan
author_facet Hua, Yue
Wang, Yuan
Kang, Xue
Xu, Fan
Han, Zhen
Zhang, Chong
Wang, Zhao-Yang
Liu, Jun-Qi
Zhao, Xueli
Chen, Xiaoyuan
Zang, Shuang-Quan
author_sort Hua, Yue
collection PubMed
description BACKGROUND: As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations. RESULTS: In this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au(4)-iron oxide nanoparticle (Au(4)-IO NP-cRGD) based on aggregation-induced emission (AIE) as a multifunctional theranostic system. Besides Au(4) cluster-based fluorescence imaging and enhanced radiotherapy, iron oxide (IO) nanocluster could realize magnetic resonance (MR) imaging and Fenton reaction-based chemotherapy. Abundant toxic reactive oxygen species generated from X-ray irradiation and in situ tumor-specific Fenton reaction under acidic microenvironment leads to the apoptotic and necrotic death of cancer cells. In vivo studies demonstrated good biocompatibility of Au(4)-IO NP-cRGD and a high tumor suppression rate of 81.1% in the synergistic therapy group. CONCLUSIONS: The successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-01191-x.
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spelling pubmed-86862912021-12-20 A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy Hua, Yue Wang, Yuan Kang, Xue Xu, Fan Han, Zhen Zhang, Chong Wang, Zhao-Yang Liu, Jun-Qi Zhao, Xueli Chen, Xiaoyuan Zang, Shuang-Quan J Nanobiotechnology Research BACKGROUND: As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations. RESULTS: In this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au(4)-iron oxide nanoparticle (Au(4)-IO NP-cRGD) based on aggregation-induced emission (AIE) as a multifunctional theranostic system. Besides Au(4) cluster-based fluorescence imaging and enhanced radiotherapy, iron oxide (IO) nanocluster could realize magnetic resonance (MR) imaging and Fenton reaction-based chemotherapy. Abundant toxic reactive oxygen species generated from X-ray irradiation and in situ tumor-specific Fenton reaction under acidic microenvironment leads to the apoptotic and necrotic death of cancer cells. In vivo studies demonstrated good biocompatibility of Au(4)-IO NP-cRGD and a high tumor suppression rate of 81.1% in the synergistic therapy group. CONCLUSIONS: The successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-01191-x. BioMed Central 2021-12-20 /pmc/articles/PMC8686291/ /pubmed/34930279 http://dx.doi.org/10.1186/s12951-021-01191-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hua, Yue
Wang, Yuan
Kang, Xue
Xu, Fan
Han, Zhen
Zhang, Chong
Wang, Zhao-Yang
Liu, Jun-Qi
Zhao, Xueli
Chen, Xiaoyuan
Zang, Shuang-Quan
A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title_full A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title_fullStr A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title_full_unstemmed A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title_short A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
title_sort multifunctional aie gold cluster-based theranostic system: tumor-targeted imaging and fenton reaction-assisted enhanced radiotherapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686291/
https://www.ncbi.nlm.nih.gov/pubmed/34930279
http://dx.doi.org/10.1186/s12951-021-01191-x
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