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p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

BACKGROUND: Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α-synuclein, chronic neuroinflammation and autophagy dysfunction. Previous studies suggested that misfolded α-synuclein induces t...

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Detalles Bibliográficos
Autores principales:	Chen, Jialong, Mao, Kanmin, Yu, Honglin, Wen, Yue, She, Hua, Zhang, He, Liu, Linhua, Li, Mingque, Li, Wenjun, Zou, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686293/ https://www.ncbi.nlm.nih.gov/pubmed/34930303 http://dx.doi.org/10.1186/s12974-021-02349-y

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