Cargando…

Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease (AD) is one of them....

Descripción completa

Detalles Bibliográficos
Autores principales: Siddiqui, Aisha, Akhtar, Sayeed, Shah, Zahoor, Othman, Iekhsan, Kumari, Yatinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686299/
https://www.ncbi.nlm.nih.gov/pubmed/32972344
http://dx.doi.org/10.2174/1570159X18666200924122732
Descripción
Sumario:It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease (AD) is one of them. However, much attention has been given to the link between tau and beta-amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via a different mechanism of inflammation. This review intends to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-LO).