Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases

Cisplatin is a platinum-containing drug that inhibits DNA synthesis by inhibiting cross-linking, denaturing DNA strands. It is used in combination with other chemotherapeutic agents to treat several types of cancers. Numerous adverse effects have been reported with this compound. However, it is cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Bin Naeem, Sameen, Azhar, Musa, Baloch, Naqib Ullah, Abbas, Mansoor, Waheed, Muhammad, Masood Sheikh, Rizwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686342/
https://www.ncbi.nlm.nih.gov/pubmed/34950548
http://dx.doi.org/10.7759/cureus.19769
_version_ 1784617998798028800
author Bin Naeem, Sameen
Azhar, Musa
Baloch, Naqib Ullah
Abbas, Mansoor
Waheed, Muhammad
Masood Sheikh, Rizwan
author_facet Bin Naeem, Sameen
Azhar, Musa
Baloch, Naqib Ullah
Abbas, Mansoor
Waheed, Muhammad
Masood Sheikh, Rizwan
author_sort Bin Naeem, Sameen
collection PubMed
description Cisplatin is a platinum-containing drug that inhibits DNA synthesis by inhibiting cross-linking, denaturing DNA strands. It is used in combination with other chemotherapeutic agents to treat several types of cancers. Numerous adverse effects have been reported with this compound. However, it is considered a safe medication in terms of cardiotoxicity. In this report, we discuss the case of two patients who experienced bradycardia while receiving cisplatin as part of combination therapy. A workup was undertaken to rule out other possible causes of bradycardia, and the diagnosis of cisplatin-induced bradycardia was made.
format Online
Article
Text
id pubmed-8686342
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-86863422021-12-22 Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases Bin Naeem, Sameen Azhar, Musa Baloch, Naqib Ullah Abbas, Mansoor Waheed, Muhammad Masood Sheikh, Rizwan Cureus Cardiology Cisplatin is a platinum-containing drug that inhibits DNA synthesis by inhibiting cross-linking, denaturing DNA strands. It is used in combination with other chemotherapeutic agents to treat several types of cancers. Numerous adverse effects have been reported with this compound. However, it is considered a safe medication in terms of cardiotoxicity. In this report, we discuss the case of two patients who experienced bradycardia while receiving cisplatin as part of combination therapy. A workup was undertaken to rule out other possible causes of bradycardia, and the diagnosis of cisplatin-induced bradycardia was made. Cureus 2021-11-20 /pmc/articles/PMC8686342/ /pubmed/34950548 http://dx.doi.org/10.7759/cureus.19769 Text en Copyright © 2021, Bin Naeem et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Bin Naeem, Sameen
Azhar, Musa
Baloch, Naqib Ullah
Abbas, Mansoor
Waheed, Muhammad
Masood Sheikh, Rizwan
Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title_full Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title_fullStr Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title_full_unstemmed Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title_short Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases
title_sort cisplatin-induced bradycardia: a silent risk observed in two different clinical cases
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686342/
https://www.ncbi.nlm.nih.gov/pubmed/34950548
http://dx.doi.org/10.7759/cureus.19769
work_keys_str_mv AT binnaeemsameen cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases
AT azharmusa cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases
AT balochnaqibullah cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases
AT abbasmansoor cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases
AT waheedmuhammad cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases
AT masoodsheikhrizwan cisplatininducedbradycardiaasilentriskobservedintwodifferentclinicalcases

Ejemplares similares