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Interleukin-1 receptor antagonist inhibits matastatic potential by down-regulating CXCL12/CXCR4 signaling axis in colorectal cancer

BACKGROUND: The aim of this study was to investigate the co-operative role of CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells and stromal cells in their microenvironment. METHODS: Expression of IL-1α, interleukin-1 receptor type I (IL-1...

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Detalles Bibliográficos
Autores principales:	Ma, Jiachi, Liang, Wanqing, Qiang, Yaosheng, Li, Lei, Du, Jun, Pan, Chengwu, Chen, Bangling, Zhang, Chensong, Chen, Yuzhong, Wang, Qingkang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686544/ https://www.ncbi.nlm.nih.gov/pubmed/34930323 http://dx.doi.org/10.1186/s12964-021-00804-0

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