The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells

BACKGROUND: Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen, progesterone and HER2 receptors and lacks efficacious targeted therapies. NEK2 is an oncogenic kinase that is significantl...

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Detalles Bibliográficos
Autores principales: Naro, Chiara, De Musso, Monica, Delle Monache, Francesca, Panzeri, Valentina, de la Grange, Pierre, Sette, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686545/
https://www.ncbi.nlm.nih.gov/pubmed/34930366
http://dx.doi.org/10.1186/s13046-021-02210-3

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