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Recent advances of nanotechnology-based tumor vessel-targeting strategies

Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal tumor microenvironment (TME), and play a vital role in the development, immune escape, metastasis and drug resistance of tumor. Tumor vessel-targeting therapy has become an important and promising direction in ant...

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Autores principales: Zhu, Dongjie, Li, Yang, Zhang, Zhengjia, Xue, Zeyu, Hua, Zhenglai, Luo, Xinyi, Zhao, Ting, Lu, Cheng, Liu, Yuanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686559/
https://www.ncbi.nlm.nih.gov/pubmed/34930293
http://dx.doi.org/10.1186/s12951-021-01190-y
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author Zhu, Dongjie
Li, Yang
Zhang, Zhengjia
Xue, Zeyu
Hua, Zhenglai
Luo, Xinyi
Zhao, Ting
Lu, Cheng
Liu, Yuanyan
author_facet Zhu, Dongjie
Li, Yang
Zhang, Zhengjia
Xue, Zeyu
Hua, Zhenglai
Luo, Xinyi
Zhao, Ting
Lu, Cheng
Liu, Yuanyan
author_sort Zhu, Dongjie
collection PubMed
description Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal tumor microenvironment (TME), and play a vital role in the development, immune escape, metastasis and drug resistance of tumor. Tumor vessel-targeting therapy has become an important and promising direction in anti-tumor therapy, with the development of five anti-tumor therapeutic strategies, including vascular disruption, anti-angiogenesis, vascular blockade, vascular normalization and breaking immunosuppressive TME. However, the insufficient drug accumulation and severe side effects of vessel-targeting drugs limit their development in clinical application. Nanotechnology offers an excellent platform with flexible modified surface that can precisely deliver diverse cargoes, optimize efficacy, reduce side effects, and realize the combined therapy. Various nanomedicines (NMs) have been developed to target abnormal tumor vessels and specific TME to achieve more efficient vessel-targeting therapy. The article reviews tumor vascular abnormalities and the resulting abnormal microenvironment, the application of NMs in the tumor vessel-targeting strategies, and how NMs can improve these strategies and achieve multi-strategies combination to maximize anti-tumor effects. [Image: see text]
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spelling pubmed-86865592021-12-20 Recent advances of nanotechnology-based tumor vessel-targeting strategies Zhu, Dongjie Li, Yang Zhang, Zhengjia Xue, Zeyu Hua, Zhenglai Luo, Xinyi Zhao, Ting Lu, Cheng Liu, Yuanyan J Nanobiotechnology Review Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal tumor microenvironment (TME), and play a vital role in the development, immune escape, metastasis and drug resistance of tumor. Tumor vessel-targeting therapy has become an important and promising direction in anti-tumor therapy, with the development of five anti-tumor therapeutic strategies, including vascular disruption, anti-angiogenesis, vascular blockade, vascular normalization and breaking immunosuppressive TME. However, the insufficient drug accumulation and severe side effects of vessel-targeting drugs limit their development in clinical application. Nanotechnology offers an excellent platform with flexible modified surface that can precisely deliver diverse cargoes, optimize efficacy, reduce side effects, and realize the combined therapy. Various nanomedicines (NMs) have been developed to target abnormal tumor vessels and specific TME to achieve more efficient vessel-targeting therapy. The article reviews tumor vascular abnormalities and the resulting abnormal microenvironment, the application of NMs in the tumor vessel-targeting strategies, and how NMs can improve these strategies and achieve multi-strategies combination to maximize anti-tumor effects. [Image: see text] BioMed Central 2021-12-20 /pmc/articles/PMC8686559/ /pubmed/34930293 http://dx.doi.org/10.1186/s12951-021-01190-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhu, Dongjie
Li, Yang
Zhang, Zhengjia
Xue, Zeyu
Hua, Zhenglai
Luo, Xinyi
Zhao, Ting
Lu, Cheng
Liu, Yuanyan
Recent advances of nanotechnology-based tumor vessel-targeting strategies
title Recent advances of nanotechnology-based tumor vessel-targeting strategies
title_full Recent advances of nanotechnology-based tumor vessel-targeting strategies
title_fullStr Recent advances of nanotechnology-based tumor vessel-targeting strategies
title_full_unstemmed Recent advances of nanotechnology-based tumor vessel-targeting strategies
title_short Recent advances of nanotechnology-based tumor vessel-targeting strategies
title_sort recent advances of nanotechnology-based tumor vessel-targeting strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686559/
https://www.ncbi.nlm.nih.gov/pubmed/34930293
http://dx.doi.org/10.1186/s12951-021-01190-y
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