Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to th...

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Autores principales: Tarantini, Francesco, Cumbo, Cosimo, Anelli, Luisa, Zagaria, Antonella, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686563/
https://www.ncbi.nlm.nih.gov/pubmed/34930475
http://dx.doi.org/10.1186/s40364-021-00347-z
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author Tarantini, Francesco
Cumbo, Cosimo
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
author_facet Tarantini, Francesco
Cumbo, Cosimo
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
author_sort Tarantini, Francesco
collection PubMed
description Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
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spelling pubmed-86865632021-12-20 Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick Tarantini, Francesco Cumbo, Cosimo Anelli, Luisa Zagaria, Antonella Specchia, Giorgina Musto, Pellegrino Albano, Francesco Biomark Res Review Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today. BioMed Central 2021-12-20 /pmc/articles/PMC8686563/ /pubmed/34930475 http://dx.doi.org/10.1186/s40364-021-00347-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tarantini, Francesco
Cumbo, Cosimo
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title_full Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title_fullStr Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title_full_unstemmed Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title_short Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
title_sort inside the biology of early t-cell precursor acute lymphoblastic leukemia: the perfect trick
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686563/
https://www.ncbi.nlm.nih.gov/pubmed/34930475
http://dx.doi.org/10.1186/s40364-021-00347-z
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