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SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis

Single-cell CRISPR screens are a promising biotechnology for mapping regulatory elements to target genes at genome-wide scale. However, technical factors like sequencing depth impact not only expression measurement but also perturbation detection, creating a confounding effect. We demonstrate on two...

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Detalles Bibliográficos
Autores principales:	Barry, Timothy, Wang, Xuran, Morris, John A., Roeder, Kathryn, Katsevich, Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686614/ https://www.ncbi.nlm.nih.gov/pubmed/34930414 http://dx.doi.org/10.1186/s13059-021-02545-2

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