Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial

BACKGROUND: Moderate to severe acute pancreatitis (AP) is associated with a high rate of complications and increased mortality, yet no targeted pharmacologic treatment currently exists. As pain is a dominant symptom in AP, patients are exposed to excess levels of both endo- and exogenous opioids, wh...

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Detalles Bibliográficos
Autores principales: Knoph, Cecilie Siggaard, Cook, Mathias Ellgaard, Fjelsted, Camilla Ann, Novovic, Srdan, Mortensen, Michael Bau, Nielsen, Liv Bjerre Juul, Hansen, Mark Berner, Frøkjær, Jens Brøndum, Olesen, Søren Schou, Drewes, Asbjørn Mohr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686628/
https://www.ncbi.nlm.nih.gov/pubmed/34924020
http://dx.doi.org/10.1186/s13063-021-05885-3

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