Rationale and design of the multicentric, double-blind, double-placebo, randomized trial APrepitant versus HYdroxyzine in association with cytoreductive treatments for patients with myeloproliferative neoplasia suffering from Persistent Aquagenic Pruritus. Trial acronym: APHYPAP

BACKGROUND: Aquagenic pruritus (AP), an intense sensation of scratching induced after water contact, is the most troublesome aspect of BCR-ABL1-negative myeloproliferative neoplasms (MPNs). Mostly described in polycythemia vera (PV, ~ 40%), it is also present in essential thrombocythemia (ET) and pr...

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Detalles Bibliográficos
Autores principales: Le Gall-Ianotto, C., Verdet, R., Nowak, E., Le Roux, L., Gasse, A., Fiedler, A., Carlhant-Kowalski, D., Marcorelles, P., Misery, L., Ianotto, J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686668/
https://www.ncbi.nlm.nih.gov/pubmed/34923994
http://dx.doi.org/10.1186/s13063-021-05864-8

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