NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance

SilE and SilB are both proteins involved in the silver efflux pump found in Gram-negative bacteria such as S. typhimurium. Using model peptides along with NMR and CD experiments, we show how SilE may store silver ions prior to delivery and we hypothesize for the first time the interplay between SilB...

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Detalles Bibliográficos
Autores principales: Babel, Lucille, Nguyen, Minh-Ha, Mittelheisser, Cédric, Martin, Marie, Fromm, Katharina M., Walker, Olivier, Hologne, Maggy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686694/
https://www.ncbi.nlm.nih.gov/pubmed/34396382
http://dx.doi.org/10.1039/d1cc02597j
Descripción
Sumario:SilE and SilB are both proteins involved in the silver efflux pump found in Gram-negative bacteria such as S. typhimurium. Using model peptides along with NMR and CD experiments, we show how SilE may store silver ions prior to delivery and we hypothesize for the first time the interplay between SilB and SilE.

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