A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19

Aim: The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials & methods: A systematic review and meta-analysis of 58 publications were performed using...

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Autores principales: Makoah, Nigel A, Tipih, Thomas, Litabe, Matefo M, Brink, Mareza, Sempa, Joseph B, Goedhals, Dominique, Burt, Felicity J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686841/
https://www.ncbi.nlm.nih.gov/pubmed/34950219
http://dx.doi.org/10.2217/fvl-2021-0211
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author Makoah, Nigel A
Tipih, Thomas
Litabe, Matefo M
Brink, Mareza
Sempa, Joseph B
Goedhals, Dominique
Burt, Felicity J
author_facet Makoah, Nigel A
Tipih, Thomas
Litabe, Matefo M
Brink, Mareza
Sempa, Joseph B
Goedhals, Dominique
Burt, Felicity J
author_sort Makoah, Nigel A
collection PubMed
description Aim: The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials & methods: A systematic review and meta-analysis of 58 publications were performed using data obtained from Academic Search Ultimate, Africa-wide, Scopus, Web of Science and MEDLINE. Results: We found that the highest pooled sensitivities were obtained with ELISA IgM-IgG and chemiluminescence immunoassay IgM tests. Conclusion: Serological tests have low sensitivity within the first week of symptom onset and cannot replace nucleic acid amplification tests. However, serological assays can be used to support nucleic acid amplification tests.
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spelling pubmed-86868412021-12-21 A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19 Makoah, Nigel A Tipih, Thomas Litabe, Matefo M Brink, Mareza Sempa, Joseph B Goedhals, Dominique Burt, Felicity J Future Virol Systematic Review Aim: The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials & methods: A systematic review and meta-analysis of 58 publications were performed using data obtained from Academic Search Ultimate, Africa-wide, Scopus, Web of Science and MEDLINE. Results: We found that the highest pooled sensitivities were obtained with ELISA IgM-IgG and chemiluminescence immunoassay IgM tests. Conclusion: Serological tests have low sensitivity within the first week of symptom onset and cannot replace nucleic acid amplification tests. However, serological assays can be used to support nucleic acid amplification tests. Future Medicine Ltd 2021-12-15 2021-11 /pmc/articles/PMC8686841/ /pubmed/34950219 http://dx.doi.org/10.2217/fvl-2021-0211 Text en © 2021 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Systematic Review
Makoah, Nigel A
Tipih, Thomas
Litabe, Matefo M
Brink, Mareza
Sempa, Joseph B
Goedhals, Dominique
Burt, Felicity J
A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title_full A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title_fullStr A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title_full_unstemmed A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title_short A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19
title_sort systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of covid-19
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686841/
https://www.ncbi.nlm.nih.gov/pubmed/34950219
http://dx.doi.org/10.2217/fvl-2021-0211
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