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Drug Repurposing for Tooth Regeneration: The Promising Premises

Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug...

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Autores principales: Divya, TC, Muddappa, Sapna Chandira, Singh, Prabath, Rajan, Rakesh R, Remya, M, Sreehari, Deepthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687015/
https://www.ncbi.nlm.nih.gov/pubmed/35017906
http://dx.doi.org/10.4103/jpbs.jpbs_67_21
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author Divya, TC
Muddappa, Sapna Chandira
Singh, Prabath
Rajan, Rakesh R
Remya, M
Sreehari, Deepthy
author_facet Divya, TC
Muddappa, Sapna Chandira
Singh, Prabath
Rajan, Rakesh R
Remya, M
Sreehari, Deepthy
author_sort Divya, TC
collection PubMed
description Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug repurposing focuses in attaining dentin repair or reduction of bone resorption associated with apical periodontitis. Metformin, an anti-diabetic drug has shown pro-osteogenic properties. Aspirin a known anti-inflammatory agent with anticoagulant action is found to modulate the differentiation of dental pulp cells. The significant role of glycogen synthase kinase-3 inhibitors in activating the Wnt/-beta cat signaling pathway of mesenchymal pulp stem cells may pave the way to the pharmacological treatment of dental caries in near future. It is to be noted here that further preclinical and clinical studies are warranted for the regular therapeutic use of these potential drugs in clinical dentistry.
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spelling pubmed-86870152022-01-10 Drug Repurposing for Tooth Regeneration: The Promising Premises Divya, TC Muddappa, Sapna Chandira Singh, Prabath Rajan, Rakesh R Remya, M Sreehari, Deepthy J Pharm Bioallied Sci Review Article Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug repurposing focuses in attaining dentin repair or reduction of bone resorption associated with apical periodontitis. Metformin, an anti-diabetic drug has shown pro-osteogenic properties. Aspirin a known anti-inflammatory agent with anticoagulant action is found to modulate the differentiation of dental pulp cells. The significant role of glycogen synthase kinase-3 inhibitors in activating the Wnt/-beta cat signaling pathway of mesenchymal pulp stem cells may pave the way to the pharmacological treatment of dental caries in near future. It is to be noted here that further preclinical and clinical studies are warranted for the regular therapeutic use of these potential drugs in clinical dentistry. Wolters Kluwer - Medknow 2021-11 2021-11-10 /pmc/articles/PMC8687015/ /pubmed/35017906 http://dx.doi.org/10.4103/jpbs.jpbs_67_21 Text en Copyright: © 2021 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Divya, TC
Muddappa, Sapna Chandira
Singh, Prabath
Rajan, Rakesh R
Remya, M
Sreehari, Deepthy
Drug Repurposing for Tooth Regeneration: The Promising Premises
title Drug Repurposing for Tooth Regeneration: The Promising Premises
title_full Drug Repurposing for Tooth Regeneration: The Promising Premises
title_fullStr Drug Repurposing for Tooth Regeneration: The Promising Premises
title_full_unstemmed Drug Repurposing for Tooth Regeneration: The Promising Premises
title_short Drug Repurposing for Tooth Regeneration: The Promising Premises
title_sort drug repurposing for tooth regeneration: the promising premises
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687015/
https://www.ncbi.nlm.nih.gov/pubmed/35017906
http://dx.doi.org/10.4103/jpbs.jpbs_67_21
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