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Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries

Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introd...

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Detalles Bibliográficos
Autores principales: Shakya, Mila, Neuzil, Kathleen M, Pollard, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687069/
https://www.ncbi.nlm.nih.gov/pubmed/34374785
http://dx.doi.org/10.1093/infdis/jiab393
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author Shakya, Mila
Neuzil, Kathleen M
Pollard, Andrew J
author_facet Shakya, Mila
Neuzil, Kathleen M
Pollard, Andrew J
author_sort Shakya, Mila
collection PubMed
description Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever.
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spelling pubmed-86870692021-12-21 Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries Shakya, Mila Neuzil, Kathleen M Pollard, Andrew J J Infect Dis Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever. Oxford University Press 2021-08-10 /pmc/articles/PMC8687069/ /pubmed/34374785 http://dx.doi.org/10.1093/infdis/jiab393 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Shakya, Mila
Neuzil, Kathleen M
Pollard, Andrew J
Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title_full Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title_fullStr Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title_full_unstemmed Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title_short Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
title_sort prospects of future typhoid and paratyphoid vaccines in endemic countries
topic Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687069/
https://www.ncbi.nlm.nih.gov/pubmed/34374785
http://dx.doi.org/10.1093/infdis/jiab393
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