Cargando…
Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries
Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introd...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687069/ https://www.ncbi.nlm.nih.gov/pubmed/34374785 http://dx.doi.org/10.1093/infdis/jiab393 |
_version_ | 1784618142073356288 |
---|---|
author | Shakya, Mila Neuzil, Kathleen M Pollard, Andrew J |
author_facet | Shakya, Mila Neuzil, Kathleen M Pollard, Andrew J |
author_sort | Shakya, Mila |
collection | PubMed |
description | Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever. |
format | Online Article Text |
id | pubmed-8687069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86870692021-12-21 Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries Shakya, Mila Neuzil, Kathleen M Pollard, Andrew J J Infect Dis Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever. Oxford University Press 2021-08-10 /pmc/articles/PMC8687069/ /pubmed/34374785 http://dx.doi.org/10.1093/infdis/jiab393 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs Shakya, Mila Neuzil, Kathleen M Pollard, Andrew J Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title | Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title_full | Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title_fullStr | Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title_full_unstemmed | Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title_short | Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries |
title_sort | prospects of future typhoid and paratyphoid vaccines in endemic countries |
topic | Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687069/ https://www.ncbi.nlm.nih.gov/pubmed/34374785 http://dx.doi.org/10.1093/infdis/jiab393 |
work_keys_str_mv | AT shakyamila prospectsoffuturetyphoidandparatyphoidvaccinesinendemiccountries AT neuzilkathleenm prospectsoffuturetyphoidandparatyphoidvaccinesinendemiccountries AT pollardandrewj prospectsoffuturetyphoidandparatyphoidvaccinesinendemiccountries |