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Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas
The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-conf...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687070/ https://www.ncbi.nlm.nih.gov/pubmed/34528085 http://dx.doi.org/10.1093/infdis/jiab449 |
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author | Birkhold, Megan Mwisongo, Aziza Pollard, Andrew J Neuzil, Kathleen M |
author_facet | Birkhold, Megan Mwisongo, Aziza Pollard, Andrew J Neuzil, Kathleen M |
author_sort | Birkhold, Megan |
collection | PubMed |
description | The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-confirmed typhoid fever in African and Asian children. Pakistan, Liberia, and Zimbabwe recently introduced TCV through campaigns and routine childhood immunizations, providing protection for this vulnerable population. It is essential to continue this momentum while simultaneously filling data gaps—including typhoid complications—to inform decision-making on TCV introduction. A multidisciplinary approach including surveillance, water, sanitation, and hygiene investments, and large-scale TCV introduction is needed to decrease the burden and mortality of typhoid fever. |
format | Online Article Text |
id | pubmed-8687070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86870702021-12-21 Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas Birkhold, Megan Mwisongo, Aziza Pollard, Andrew J Neuzil, Kathleen M J Infect Dis Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-confirmed typhoid fever in African and Asian children. Pakistan, Liberia, and Zimbabwe recently introduced TCV through campaigns and routine childhood immunizations, providing protection for this vulnerable population. It is essential to continue this momentum while simultaneously filling data gaps—including typhoid complications—to inform decision-making on TCV introduction. A multidisciplinary approach including surveillance, water, sanitation, and hygiene investments, and large-scale TCV introduction is needed to decrease the burden and mortality of typhoid fever. Oxford University Press 2021-09-16 /pmc/articles/PMC8687070/ /pubmed/34528085 http://dx.doi.org/10.1093/infdis/jiab449 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs Birkhold, Megan Mwisongo, Aziza Pollard, Andrew J Neuzil, Kathleen M Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title | Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title_full | Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title_fullStr | Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title_full_unstemmed | Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title_short | Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas |
title_sort | typhoid conjugate vaccines: advancing the research and public health agendas |
topic | Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687070/ https://www.ncbi.nlm.nih.gov/pubmed/34528085 http://dx.doi.org/10.1093/infdis/jiab449 |
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