Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework

In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically im...

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Detalles Bibliográficos
Autores principales: Dyson, Zoe A, Holt, Kathryn E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687072/
https://www.ncbi.nlm.nih.gov/pubmed/34453548
http://dx.doi.org/10.1093/infdis/jiab414
Descripción
Sumario:In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically important subpopulations, which require the definition of new genotypes and extension of associated software to facilitate the detection of antimicrobial resistance (AMR) mutations. Analysis of 4632 WGS provide an updated overview of the global S Typhi population structure and genotyping framework, revealing the widespread nature of haplotype 58 ([H58] 4.3.1) genotypes and the diverse range of genotypes carrying AMR mutations.

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