Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework

In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically im...

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Autores principales: Dyson, Zoe A, Holt, Kathryn E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687072/
https://www.ncbi.nlm.nih.gov/pubmed/34453548
http://dx.doi.org/10.1093/infdis/jiab414
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author Dyson, Zoe A
Holt, Kathryn E
author_facet Dyson, Zoe A
Holt, Kathryn E
author_sort Dyson, Zoe A
collection PubMed
description In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically important subpopulations, which require the definition of new genotypes and extension of associated software to facilitate the detection of antimicrobial resistance (AMR) mutations. Analysis of 4632 WGS provide an updated overview of the global S Typhi population structure and genotyping framework, revealing the widespread nature of haplotype 58 ([H58] 4.3.1) genotypes and the diverse range of genotypes carrying AMR mutations.
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spelling pubmed-86870722021-12-21 Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework Dyson, Zoe A Holt, Kathryn E J Infect Dis Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically important subpopulations, which require the definition of new genotypes and extension of associated software to facilitate the detection of antimicrobial resistance (AMR) mutations. Analysis of 4632 WGS provide an updated overview of the global S Typhi population structure and genotyping framework, revealing the widespread nature of haplotype 58 ([H58] 4.3.1) genotypes and the diverse range of genotypes carrying AMR mutations. Oxford University Press 2021-08-28 /pmc/articles/PMC8687072/ /pubmed/34453548 http://dx.doi.org/10.1093/infdis/jiab414 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Dyson, Zoe A
Holt, Kathryn E
Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title_full Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title_fullStr Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title_full_unstemmed Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title_short Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework
title_sort five years of genotyphi: updates to the global salmonella typhi genotyping framework
topic Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687072/
https://www.ncbi.nlm.nih.gov/pubmed/34453548
http://dx.doi.org/10.1093/infdis/jiab414
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