Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh

Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The Internatio...

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Autores principales: Zaman, K, Aziz, Asma Binte, Yunus, Md, Qadri, Firdausi, Ross, Allen G, Clemens, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687083/
https://www.ncbi.nlm.nih.gov/pubmed/34528671
http://dx.doi.org/10.1093/infdis/jiab442
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author Zaman, K
Aziz, Asma Binte
Yunus, Md
Qadri, Firdausi
Ross, Allen G
Clemens, John D
author_facet Zaman, K
Aziz, Asma Binte
Yunus, Md
Qadri, Firdausi
Ross, Allen G
Clemens, John D
author_sort Zaman, K
collection PubMed
description Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has completed several groundbreaking RV trials (Phase I–Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh.
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spelling pubmed-86870832021-12-21 Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh Zaman, K Aziz, Asma Binte Yunus, Md Qadri, Firdausi Ross, Allen G Clemens, John D J Infect Dis Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has completed several groundbreaking RV trials (Phase I–Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh. Oxford University Press 2021-09-16 /pmc/articles/PMC8687083/ /pubmed/34528671 http://dx.doi.org/10.1093/infdis/jiab442 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Zaman, K
Aziz, Asma Binte
Yunus, Md
Qadri, Firdausi
Ross, Allen G
Clemens, John D
Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title_full Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title_fullStr Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title_full_unstemmed Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title_short Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh
title_sort rotavirus vaccine trials in international centre for diarrhoeal disease research, bangladesh (icddr,b) and future use of the vaccine in bangladesh
topic Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687083/
https://www.ncbi.nlm.nih.gov/pubmed/34528671
http://dx.doi.org/10.1093/infdis/jiab442
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